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(nou) that part of the central nervous system that includes all the higher nervous centers; enclosed within the skull; continuous with the spinal cord (nou) mental ability (nou) that which is responsible for one's thoughts and feelings; the seat of the faculty of reason (nou) someone who has exceptional intellectual ability and originality (nou) the brain of certain animals used as meat

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The disease is characterized by hardening of the brain tissues.

Pyromania is obviously not a disease or a brain deficiency, it's a personality.

The brain is in the head, encircling and mainly 'above' the esophagus.

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