the preposition 'out of' typically indicates spatial relationships and movement and is used to describe movement away from something or months, years, etc.
He saw the cat run out of the room.
He had been out of breath for a while.
She was a long way out of town.
in the examples, the phrase 'out of' cannot be replaced with any other single word. In some cases, however, it can be replaced with a more specific preposition such as 'from' or 'off.'